بررسی پاپیلوما ویروس انسانی در افراد مبتلا به سرطان مثانه و گروه شاهد با روش PCR

Background: Bladder cancer is the second prevalent cancer of urogenital tract, affecting males 3 more commonly than females. Different risk factors have been proposed, among which viral infections, especially HPV, have been explained recently. The present study surveyed HPV and its associated types in patients with bladder cancer using PCR technique. Materials and methods: A total of 186 patients, including 147 cases and 39 controls were biopsied and HPV frequency and its associated types were determined by PCR Results: Totally, 34.7% of cases and 7.6% of controls were HPV positive. HPV18 was the most frequent type (47%). Males were 6 times more frequently affected than females. Most of the cases were aged 51-60 years. Conclusion: With respect to the high frequency rate of HPV among patients with bladder cancer when compared with controls, HPV seems to be significantly associated with bladder cancer.